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Analytik Jena | Biometra Thermal Cyclers

Biometra Thermal Cyclers
30 years PCR competence for research and routine use
  • Our PCR expertise for your important samples
  • Suitable solutions for different requirements
  • Sophisticated operating concepts for error-free PCR results
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  • Features
  • Specifications
  • Order information

Tab 0

Simply the Best in PCR
In the Analytik Jena thermal cycler portfolio, every user will find the right device: The Biometra product family offers PCR devices ranging from standard to premium equipment – all designed in line with the common principles of being reliable, convenient, and precise.
  • Designed for error-free use in versatile laboratory environments: universal block design and heating lid with High-Performance Smart Lid (HPSL) technology for unrestricted use of different plastic containers and plates
  • Easily optimize your PCR protocols using the Linear Gradient Function (LGT) or the TOS (Temperature Optimization Step) function
  • Full reliability of your results: The high-precision block temperature control system provides high heating and cooling rates and excellent temperature homogeneity for constant conditions across all sample positions.
 
Intelligent with detailed precision
Featuring top quality and detailed precision, Biometra thermal cyclers make your lab workday easier and ensure excellent results.
 
  • Self-explanatory, rapid operations with graphics and table programming options
  • Easy to use, thanks to the protocol wizard, and GLP-compliant through the advanced user management in the Biometra TAdvanced and Biometra TRIO systems
  • Whisper-quiet and small footprint: optimum air flow control ensures maximum performance in any laboratory
  • Continual information on the device’s status through the extended self-test
Biometra TAdvanced and TRIO – Product Animation
The Biometra TAdvanced is the high-performance thermal cycler for DNA amplification by PCR.
 
The Biometra TRIO is a triple powered thermal cycler for PCR providing three independent sample blocks which can run three different PCR reactions in parallel.
 
 

 

Essential for research – gradient function
For rapid success, it is essential to have suitable tools at hand. For polymerase chain reactions (PCR), optimization of the annealing temperatures is crucial when it comes to achieving accurate results. Depending on the device type, the Biometra thermal cyclers offer a linear gradient function or a temperature optimization function for this purpose. In the Biometra TOne and Biometra TAdvanced systems, a temperature gradient over the long side of the block is realized as linearly as possible through special block construction and precise electronics. Users only need to enter the desired temperature step size and the annealing temperature for the middle of the block. In the Biometra TRIO three-block device, the TOS function rapidly sets three different annealing temperatures in the three blocks. The programs are started simultaneously. Therefore optimal amplification conditions can be found quickly during a PCR run.
 
  • Optimization of the PCR protocol for new primer pairs in one run
  • Optimal annealing temperatures lead to the best specificity and yield
  • Easy transfer of results thanks to largely linear temperature steps from column to column
 
Quality through design, innovation and experiences
Biometra thermal cyclers are designed so users can rely on their results. The data accuracy of these systems pairs exceedingly well with its easy to use design.
 
  • Sophisticated temperature control system without exceeding or falling below the target temperature ensures transparency and maximum experimental reproducibility in all block positions
  • The High-Performance Smart Lid (HPSL) ensures uniform temperatures and no condensation in the cover/block space, regardless of the plastic materials used
  • The extremely quiet operation allows for the use of a large number of cyclers in labs with office areas
  • Broad and versatile for sample vessels due to the universal block design and adjusting cover pressure
  • Well designed selection of equipment for every need, with a broad range of block materials and formats
  • Low space requirements thanks to an efficient air flow design

 

PCR Control App

Easy and uncomplicated
In addition to simple programming directly on the device, Biometra thermal cyclers can be accessed through a network via smartphone or tablet. The PCR Control App also allows for the control and monitoring of devices outside of the laboratory, opening up completely new possibilities.
 
The iOS- and Android-compatible software has much to offer for the Biometra TOne, Biometra TAdvanced and Biometra TRIO:
  • Live monitoring of PCR runs
  • Starting and stopping runs
  • Saving and copying programs
  • Reading of parameters and notifications

Tab 1

 

Technology Overview

Unique feature Biometra TOne Biometra TAdvanced Biometra TRIO
Fast Ramping, Highest Accuracy, Block/Well Control  ✓✓
Whisper Quiet technology
High-Performance Smart Lid
Quick Block Exchange    
Linear Gradient Tool  
Approximate linear temperature increment In rows 4 to 8 In rows 3 to 10  
Temperature Optimization Step    
Protocol Wizard  
Advanced User Management  
Three block system    
Twin block model    
PCR Control App


Biometra TOne

Modell

Biometra TOne 96

Biometra TOne 96 G

Capacity  96 x 0.2 ml tubes/ 96 well microtiter plate/12 x 8 well strips, 0.2 ml

Block

Aluminum, special alloy

Max. heating rate1

4.0 °C/s

Max. cooling rate1 3.3 °C/s

Max./min. gradient2

-

20 °C/0.1 °C

Gradient  temperature range2

-

20 °C bis 99 °C

Temperature uniformity at 55 °C after 15 s

± 0.20 °C

Temperature range

3 °C bis 99 °C

Control accuracy

± 0.1 °C

Lid temperature range

30 °C bis 110 °C

Software

User-specific quick start option for the five most recent programs; program preview before start; option for toggling
between table and graph programming mode; Linear Gradient Tool; Service Info Files (SINF) generation; expanded selftest; adjustable heating and cooling rates; gradient temperature diagram view; thermal cycler control via PCR Control App

Program memory 350 programs à 6 steps in up to 90 user directories
Language English, German, Chinese

Dimensions (W x D x H, mm)

260 x 430 x 241

 
G = with gradient function 
1  measured within sample block 
2 applies only to cycler models with gradient function
For more technical details please refer to the corresponding Technical Data sheets.

 

 

Biometra TAdvanced

Model

Biometra TAdvanced
96/96 G

Biometra TAdvanced
96 S/96 SG

Biometra TAdvanced
60/60 G

Biometra TAdvanced
384/384 G

Biometra TAdvanced
Twin 48/48 G3

Biometra TAdvanced
Twin 30

Biometra TAdvanced
Twin Combi

Capacity  96 x 0.2 ml tubes/ 96 well microtiter plate/ 12 x 8 well strips, 0.2 ml 96 x 0.2 ml tubes/ 96 well microtiter plate/ 12 x 8 well strips, 0.2 ml 60 x 0.5 ml tubes 384 well microplate 2 x 48 x 0.2 ml tubes/ 2 x 48 well microtiter plate / 2 x 6 x 8 well strips, 0.2 ml

2 x 30 x 0.5 ml tubes

2 x 48 x 0.2 ml tubes/ 2 x 6 x 8 well strips, 0.2 ml/ 2 x 48 well microtiter plate/ 2 x 18x 0.5 ml tubes

Block

Aluminum, 
special alloy

Silver,
gold-coated
Aluminum, 
special alloy
Aluminum, 
special alloy
Aluminum, 
special alloy
Aluminum, 
special alloy
Aluminum, 
special alloy

Block exchange

Quick-X-Change

Duration
block
exchange

Less than 10 s

Max.
heating rate*

6.0 °C/s

8.0 °C/s

6.0 °C/s

4.0 °C/s

5.2 °C/s

4.2 °C/s

3.1 °C/s

Max.
cooling rate*

4.0 °C/s

5.5 °C/s

4.0 °C/s

2.0 °C/s

4.1 °C/s 3.3 °C/s 2.3 °C/s

Avg.
heating rate*

5.5 °C/s

7.0 °C/s

5.5 °C/s

3.8 °C/s

5.1 °C/s 4.1 °C/s 3.0 °C/s

Avg.
cooling rate*

3.5 °C/s

4.5 °C/s

3.0 °C/s

1.7 °C/s

4.0 °C/s 3.1 °C/s 2.0 °C/s

Max./Min. gradient*

30 °C/0.1 °C

40 °C/0.1 °C

30 °C/0.1 °C

24 °C/0.1 °C

20 °C/0.1 °C3

- -
Temperature uniformity 

95 °C ± 0.60 °C after 15 s
70 °C ± 0.30 °C after 15 s
55 °C ± 0.20 °C after 15 s

95 °C ± 0.50 °C after 15 s
70 °C ± 0.25 °C after 15 s
55 °C ± 0.15 °C after 15 s

95 °C ± 0.60 °C after 15 s
70 °C ± 0.25 °C after 15 s
55 °C ± 0.20 °C after 15 s

95 °C ± 0.50 °C after 15 s
70 °C ± 0.25 °C after 15 s
55 °C ± 0.15 °C after 15 s

95 °C ± 0.60 °C after 15 s
70 °C ± 0.30 °C after 15 s
55 °C ± 0.20 °C after 15 s
95 °C ± 0.60 °C after 15 s
70 °C ± 0.30 °C after 15 s
55 °C ± 0.20 °C after 15 s
95 °C ± 0.50 °C after 15 s
70 °C ± 0.25 °C after 15 s
55 °C ± 0.20 °C after 15 s

Gradient temperature range1

20 °C to 99 °C

4 °C to 99 °C

- - 20 °C to 99 °C - -
Temperature range

3 °C to 99 °C

Control accuracy ± 0.1 °C

Software

User-specific quick start option for the five most recent programs; program preview before start; option for toggling between table and graph programming mode; Linear Gradient Tool1; Service Info Files (SINF) generation; expanded self-test; adjustable heating and cooling rates; gradient temperature diagram view1; thermal cycler control via PCR Control App; comprehensive user administration tool; Protocol Wizard

Program memory

350 programs à 6 steps in up to 90 user directories

Language English, German, Chinese

Display

7“ color touchscreen
Automatic restart after power failure

Yes

High Performance
Smart Lid (HPSL) technology

Yes
Heated lid temperature range

30 °C to 110 °C

Power consumption

850 Watt

Operating voltage

100, 115, 230 Volt, 50–60 Hz

Noise emission

Very low

interfaces2

USB A, Ethernet

Ambient conditions

15 °C to 35 °C, 70 % humidity, max. 2.000 m NN

Dimensions 
(B x T x H)

277 mm x 457 mm x 264 mm

Dimensions
(B x T x H) with open lid

277 mm x 457 mm x 414 mm

Weight

15 kg

 

* measured within sample block
1 only for model type „G“ with gradient function 
2 The network cable must be at least Cat 5e and the cable configuration must be STP.
Gradient feature included in on e block of the twin-block module.
4 The capacity increases to 35 x 0.5 ml tubes when using tubes with small caps.

Biometra TRIO

 

Biometra TRIO 30

Biometra
TRIO 48

Biometra
TRIO combi

Capacity  3 blocks for 30 x 0.5 ml tubes each

3 blocks for 48 x 0.2 ml tubes or
48 well microplates or
6 x strips of 8 each

3 combi blocks for 18 x 0.5 ml tubes**
or 48 x 0.2 ml tubes,
or 48 well microplates
or 6 x strips of 8
Max. heating rate*

4.0 °C/s

5.0 °C/s

3.0 °C/s

Max. cooling rate*

3.6° C/s

4.2 °C/s

2.7 °C/s

Temperature uniformity

±0.20 °C after 15 s at 50 °C
±0.30 °C after 15 s at 70 °C
±0.60 °C after 15 s at 95 °C

Temperature range

3 °C to 99 °C

Control accuracy

+/- 0.1 °C

Software

User specific quick start of the last five programs, program preview prior to start, toggle between spread-sheet and graphical programming mode, Temperature Optimization Step (TOS), Service Info Files (SINF), Extended Self-Test (EST), adjustable ramp rates,  thermal cycler control via PCR Control App, comprehensive user administration tool, protocol wizard, annealing temperature calculator
Program memory 350 programs à 6 steps in up to 90 user directories
Language English, German, Chinese

Display

7“ color touchscreen
Automatic restart after power failure

Yes

High-Performance Smart Lid (HPSL) technology

Yes

Lid temperature range

30 °C to 110 °C

Power consumption

1000 Watt

Power supply

100 V, 115 V, 230 V, 50–60 Hz

Noise emission

Very low

Interfaces1

USB A, Ethernet

Ambient conditions

15 °C bis 35 °C, 70 % humidity, max. 2.000 m NN

Dimensions (B x H x T)

300 mm x 250 mm x 410 mm

Weight

17.3 kg

 

* measured within sample block 
** capacity increases to 35 x 0.5 ml tubes by use of small cap tubes
1 the network cable must be at least performance class Cat 5e and the cable configuration has to be STP

Biometra TRobot

Model

Biometra TRobot 96

Biometra TRobot 384

Sample capacity 96 well microplate  348 well microplate
Block silver block, gold-plated  aluminum block, special alloy
Max. heating rate

3.5 °C/s  

1.0 °C/s
Max. cooling rate 2.5 °C/s 1.0 °C/s

Dimensions (W x D x H, mm)

168 x 226 x 195 / 306  (lid closed / lid open)

 

 

 

 

Tab 2

Biometra TOne

Order Number Description

846-x-070-311

Biometra TOne 96 with 96 well sample block (0.2 ml)

846-x-070-301

Biometra TOne 96 G with 96 well sample block (0.2 ml) and gradient function

x = 2 for 230 V, 4 for 115 V, 5 for 100 V, 50 - 60 Hz

 

Biometra TAdvanced

Order Number Description

846-x-070-211

Biometra TAdvanced 96 with 96 well block (0.2 ml)

846-x-070-201

Biometra TAdvanced 96 G with 96 well block (0.2 ml) and gradient function

846-x-070-251

Biometra TAdvanced 96 S with 96 well block (silver, 0.2 ml)

846-x-070-241

Biometra TAdvanced 96 SG with 96 well block (silver, 0.2 ml) and gradient function

846-x-070-210

Biometra TAdvanced 60 with 60 well block (0.5 ml)

846-x-070-200

Biometra TAdvanced 60 G with 60 well block (0.5 ml) and gradient function

846-x-070-224

Biometra TAdvanced 384 with 384 well block

846-x-070-214

Biometra TAdvanced 384 G with 384 well block and gradient function

846-x-070-212

Biometra TAdvanced Twin 48 with 2 x 48 well block (0.2 ml)

846-x-070-202

Biometra TAdvanced Twin 48 G with 2 x 48 well block (0.2 ml) and gradient function in one block

846-x-070-213

Biometra TAdvanced Twin 30 with 2 x 30 well block (0.5 ml)

846-x-070-215

Biometra TAdvanced Twin Combi with 2 x 48 well (0.2 ml) and 2 x 18 well (0.5 ml) block

x = 2 for 230 V, 4 for 115 V, 5 for 100 V, 50 - 60 Hz

 

Biometra TAdvanced – Block modules and base unit

Order Number Description

846-070-231

Block module 96 with 96 well block (0.2 ml)

846-070-221

Block module 96 G with 96 well block (0.2 ml) and gradient function

846-070-271

Block module 96 S with 96 well block (silver, 0.2 ml)

846-070-261

Block module 96 SG with 96 well block (silver, 0.2 ml) and gradient function

846-070-230

Block module 60 with 60 well block (0.5 ml)

846-070-220

Block module 60 G with 60 well block (0.5 ml) and gradient function

846-070-234

Block module 384 with 384 well block

846-070-224

Block module 384 G with 384 well block and gradient function

846-070-232

Twin block module 48 with 2 x 48 well block (0.2 ml)

846-070-222

Twin block module 48 G with 2 x 48 well block (0.2 ml) and gradient function in one block

846-070-233

Twin block module 30 with 2 x 30 well block (0.5 ml)

846-070-235

Twin block module Combi with 2 x 48 well (0.2 ml) and 2 x 18 well (0.5 ml) block

846-x-070-280

Biometra TAdvanced base unit

x = 2 for 230 V, 4 for 115 V, 5 for 100 V, 50 - 60 Hz

 

Biometra TRIO

Order number Description

846-x-070-723

Biometra TRIO 48 with 3 x 48 well block (0.2 ml)

846-x-070-720

Biometra TRIO 30 with 3 x 30 well block (0.5 ml)

846-x-070-724

Biometra TRIO Combi with 3 x 48 well (0.2 ml) and 3 x 18 well (0.5 ml)

x = 2 for 230 V, 4 for 115 V, 5 for 100 V, 50 - 60 Hz

Biometra TRobot thermal cyclers for integration in robotic systems

Order Number Description
846-050-991

Biometra TRobot 96 with 96 well block 

846-050-992

Biometra TRobot 384 with 384 well block